Kimia Biosciences Limited

Luliconazole

General Information:

Luliconazole, trade names Luzu among others, is an imidazole antifungal medication. As a 1% topical cream, It is indicated for the treatment of athlete’s foot, jock itch, and ringworm caused by dermatophytes such as Trichophyton rubrum, Microsporumgypseum[2], and Epidermophyton floccosum.

CAS No.

187164-19-8

Therapeutic Category:

Anti –Fungal drugs

IUPAC Name:

(2E)-2-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-ylacetonitrile

Molecular Formula:

C14H9Cl2N3S2

Molecular Weight:

C14H9Cl2N3S2

Molecular Structure:

Luliconazole

Mechanism of Action

Luliconazole is an antifungal that belongs to the azole class. Although the exact mechanism of action against dermatophytes is unknown, luliconazole appears to inhibit ergosterol synthesis by inhibiting the enzyme lanosterol demethylase. Inhibition of this enzyme’s activity by azoles results in decreased amounts of ergosterol, a constituent of fungal cell membranes, and a corresponding accumulation of lanosterol.